Research Topic

force field

10 publications exploring this topic

2021

2021
cited94

Teaching a neural network to attach and detach electrons from molecules

Zubatyuk R., Smith J. S., Nebgen B. T., Tretiak S., Isayev O.

Nature Communications, 12 (2021)

Ml Potentials
Reactions Reactivity
Drug Discovery
Quantum Chemistry

Abstract Interatomic potentials derived with Machine Learning algorithms such as Deep-Neural Networks (DNNs), achieve the accuracy of high-fidelity quantum mechanical (QM) methods in areas traditionally dominated by empirical force fields and allow performing massive simulations.

DOI
2021
cited3

Teaching a Neural Network to Attach and Detach Electrons from Molecules

Zubatyuk R., Smith J., Nebgen B. T., Tretiak S., Isayev O.

(2021)

Ml Potentials
Reactions Reactivity
Drug Discovery
Quantum Chemistry

Physics-inspired Artificial Intelligence (AI) is at the forefront of methods development in molecular modeling and computational chemistry.

DOI

2020

2020
cited3

Extending the Applicability of the ANI Deep Learning Molecular Potential to Sulfur and Halogens

Devereux C., Smith J., Davis K., Barros K., Zubatyuk R., Isayev O., Roitberg A.

(2020)

Ml Potentials
Reactions Reactivity

Machine learning (ML) methods have become powerful, predictive tools in a wide range of applications, such as facial recognition and autonomous vehicles.

DOI
2020
cited63

Towards chemical accuracy for alchemical free energy calculations with hybrid physics-based machine learning / molecular mechanics potentials

Rufa D. A., Bruce Macdonald H. E., Fass J., Wieder M., Grinaway P. B., Roitberg A. E., Isayev O., Chodera J. D.

(2020)

Drug Discovery
Ml Potentials

Towards chemical accuracy for alchemical free energy calculations with hybrid physics-based machine learning / molecular mechanics potentials.

DOI
2020
cited7

Teaching a Neural Network to Attach and Detach Electrons from Molecules

Zubatyuk R., Smith J., Nebgen B. T., Tretiak S., Isayev O.

(2020)

Ml Potentials
Reactions Reactivity
Drug Discovery
Quantum Chemistry

Physics-inspired Artificial Intelligence (AI) is at the forefront of methods development in molecular modeling and computational chemistry.

DOI

2019

2019
cited531

Approaching coupled cluster accuracy with a general-purpose neural network potential through transfer learning

Smith J. S., Nebgen B. T., Zubatyuk R., Lubbers N., Devereux C., Barros K., Tretiak S., Isayev O., Roitberg A. E.

Nature Communications, 10 (2019)

Quantum Chemistry
Ml Potentials

Abstract Computational modeling of chemical and biological systems at atomic resolution is a crucial tool in the chemist’s toolset.

DOI
2019
cited5

Approaching coupled cluster accuracy with a general-purpose neural network potential through transfer learning

S Smith J., Nebgen B. T., Zubatyuk R., Lubbers N., Devereux C., Barros K., Tretiak S., Isayev O., Roitberg A.

(2019)

Quantum Chemistry
Ml Potentials

Computational modeling of chemical and biological systems at atomic resolution is a crucial tool in the chemist's toolset.

DOI
2019
cited5

Approaching coupled cluster accuracy with a general-purpose neural network potential through transfer learning

S Smith J., Nebgen B. T., Zubatyuk R., Lubbers N., Devereux C., Barros K., Tretiak S., Isayev O., Roitberg A.

(2019)

Quantum Chemistry
Ml Potentials

Computational modeling of chemical and biological systems at atomic resolution is a crucial tool in the chemist's toolset.

DOI

2018

2018

Discovering a Transferable Charge Assignment Model Using Machine Learning

Sifain A. E., Lubbers N., Nebgen B. T., Smith J. S., Lokhov A. Y., Isayev O., Roitberg A. E., Barros K., Tretiak S.

(2018)

Partial atomic charge assignment is of immense practical value to force field parametrization, molecular docking, and cheminformatics.

DOI

2017

2017
cited1243

ANI-1: an extensible neural network potential with DFT accuracy at force field computational cost

Smith J. S., Isayev O., Roitberg A. E.

Chemical Science, 8, 3192–3203 (2017)

Ml Potentials
Quantum Chemistry

We demonstrate how a deep neural network (NN) trained on a data set of quantum mechanical (QM) DFT calculated energies can learn an accurate and transferable atomistic potential for organic molecules containing H, C, N, and O atoms.

DOI