Research Topic

active learning

11 publications exploring this topic

2025

2025
cited2

Machine Learning anomaly detection of automated HPLC experiments in the Cloud Laboratory

Gusev F., Kline B. C., Quinn R., Xu A., Smith B., Frezza B., Isayev O.

(2025)

Experiment Automation

Automation of experiments in cloud laboratories promises to revolutionize scientific research by enabling remote experimentation and improving reproducibility.

DOI
2025

Discovery of Novel Celecoxib Polymorphs Using AIMNet2 Machine Learning Interatomic Potential

Zheng P., Abramov Y., Sun C. C., Isayev O.

(2025)

Ml Potentials
Experiment Automation
Drug Discovery
Materials Informatics

Polymorphism plays a pivotal role in defining the solid-state properties of pharmaceutical compounds, yet the discovery and accurate energy ranking of polymorphs remain a challenge.

DOI

2023

2023
cited44

Active Learning Guided Drug Design Lead Optimization Based on Relative Binding Free Energy Modeling

Gusev F., Gutkin E., Kurnikova M. G., Isayev O.

J. Chem. Inf. Model., 63, 583–594 (2023)

Drug Discovery
Experiment Automation

Active Learning Guided Drug Design Lead Optimization Based on Relative Binding Free Energy Modeling.

DOI
2023

Exploring the frontiers of condensed-phase chemistry with a general reactive machine learning potential

Messerly R., Zhang S., Makoś M., Jadrich R., Kraka E., Barros K., Nebgen B., Tretiak S., Isayev O., Lubbers N., Smith J.

(2023)

Ml Potentials
Experiment Automation
Reactions Reactivity

Abstract Reactive chemistry atomistic simulation has a broad range of applications from drug design to energy to materials discovery.

DOI

2022

2022
cited4

Active learning guided drug design lead optimization based on relative binding free energy modeling

Gusev F., Gutkin E., Kurnikova M. G., Isayev O.

(2022)

Drug Discovery
Experiment Automation

In silico identification of potent protein inhibitors commonly requires prediction of a ligand binding free energy (BFE).

DOI

2021

2021
cited11

Active Learning in Bayesian Neural Networks for Bandgap Predictions of Novel Van der Waals Heterostructures

Fronzi M., Isayev O., Winkler D. A., Shapter J. G., Ellis A. V., Sherrell P. C., Shepelin N. A., Corletto A., Ford M. J.

Advanced Intelligent Systems, 3 (2021)

Experiment Automation

The bandgap is one of the most fundamental properties of condensed matter.

DOI

2020

2020
cited212

The ANI-1ccx and ANI-1x data sets, coupled-cluster and density functional theory properties for molecules

Smith J. S., Zubatyuk R., Nebgen B., Lubbers N., Barros K., Roitberg A. E., Isayev O., Tretiak S.

Scientific Data, 7 (2020)

Ml Potentials
Quantum Chemistry
Experiment Automation

Abstract Maximum diversification of data is a central theme in building generalized and accurate machine learning (ML) models.

DOI
2020
cited2

The ANI-1ccx and ANI-1x Data Sets, Coupled-Cluster and Density Functional Theory Properties for Molecules

Smith J. S., Zubatyuk R., Nebgen B. T., Lubbers N., Barros K., Roitberg A., Isayev O., Tretiak S.

(2020)

Quantum Chemistry
Ml Potentials
Experiment Automation

Maximum diversification of data is a central theme in building generalized and accurate machine learning (ML) models.

DOI
2020
cited2

The ANI-1ccx and ANI-1x Data Sets, Coupled-Cluster and Density Functional Theory Properties for Molecules

Smith J. S., Zubatyuk R., Nebgen B. T., Lubbers N., Barros K., Roitberg A., Isayev O., Tretiak S.

(2020)

Quantum Chemistry
Ml Potentials
Experiment Automation

Maximum diversification of data is a central theme in building generalized and accurate machine learning (ML) models.

DOI

2019

2019

The ANI-1ccx and ANI-1x Data Sets, Coupled-Cluster and Density Functional Theory Properties for Molecules

Smith J. S., Zubatyuk R., Nebgen B. T., Lubbers N., Barros K., Roitberg A., Isayev O., Tretiak S.

(2019)

Quantum Chemistry
Ml Potentials
Experiment Automation

Maximum diversification of data is a central theme in building generalized and accurate machine learning (ML) models.

DOI

2018

2018
cited682

Less is more: Sampling chemical space with active learning

Smith J. S., Nebgen B., Lubbers N., Isayev O., Roitberg A. E.

The Journal of Chemical Physics, 148 (2018)

Generative Ai
Experiment Automation

The development of accurate and transferable machine learning (ML) potentials for predicting molecular energetics is a challenging task.

DOI